BDBM50507645 CHEMBL4473820
SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1cc(cs1)C#N
InChI Key InChIKey=HGLWPJISHDLCTE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 59 hits for monomerid = 50507645
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.735nMAssay Description:Inhibition of human FLT3 D835Y mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 2.20nMAssay Description:Binding affinity to wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system after 60 mins by Kinomescan m...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 2.80nMAssay Description:Binding affinity to wild-type human partial length FLT3 (H564 to Y969 residues) expressed in mammalian expression system after 60 mins by Kinomescan ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 5.60nMAssay Description:Binding affinity to wild-type human partial length autoinhibited FLT3 (H564 to Y969 residues) expressed in mammalian expression system after 60 mins ...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of human c-KIT using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 47nMAssay Description:Binding affinity to wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system after 60 mins by Kinomescan...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human c-KIT using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Binding affinity to human partial length FLT3 ITD/D835V double mutant expressed in bacterial expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 72nMAssay Description:Binding affinity to wild-type human partial length autoinhibited KIT (Y545 to D952 residues) expressed in mammalian expression system after 60 mins b...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 84nMAssay Description:Binding affinity to wild-type human partial length autoinhibited CSF1R (Y538 to S939 residues) expressed in mammalian expression system after 60 mins...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 87nMAssay Description:Binding affinity to human partial length FLT3 ITD/F691L double mutant expressed in bacterial expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 280nMAssay Description:Binding affinity to human non-phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding affinity to human phosphorylated ABL1 Q252H mutant expressed in mammalian expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 350nMAssay Description:Binding affinity to human non-phosphorylated ABL1 Q252H mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
Affinity DataKd: 370nMAssay Description:Binding affinity to wild-type human non-phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomes...More data for this Ligand-Target Pair
Affinity DataKd: 390nMAssay Description:Binding affinity to human phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
Affinity DataKd: 460nMAssay Description:Binding affinity to human phosphorylated ABL1 F317L mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to human phosphorylated ABL1 T315I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Binding affinity to wild-type human phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomescan ...More data for this Ligand-Target Pair
Affinity DataKd: 580nMAssay Description:Binding affinity to human non-phosphorylated ABL1 T315I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
Affinity DataIC50: 792nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Ho...More data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Ho...More data for this Ligand-Target Pair
Affinity DataIC50: 931nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 962nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human CHK1 using KKKVSRSGLYRSPSMPENLNRPR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of human CHK1 using KKKVSRSGLYRSPSMPENLNRPR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human NEK2 using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Hotspot ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of human NEK2 using MBP as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by Hotspot ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human c-SRC using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human c-SRC using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of human CDK6/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human CDK6/cyclin-D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair