BDBM50509398 CHEMBL4438957

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)O[C@@H]3[C@@H](COP(S)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3O)n1cnc2c(N)ncnc12

InChI Key InChIKey=NVOTUSOAWRDABP-ZNFLLBLTSA-N

Data  1 Kd  20 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50509398   

TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataKd:  5nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  70nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  7.07E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  1.20E+5nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  90nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  190nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  7.07E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  7.00E+3nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509398(CHEMBL4438957)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed