BDBM50509421 CHEMBL4577528

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key InChIKey=VSWSFOHKUMIXAS-XBNNLADJSA-N

Data  1 IC50  10 EC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50509421   

TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  1.38E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  10nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  10nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  30nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataIC50:  0.700nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  1.95E+5nMAssay Description:Activation of wild-type human STING expressed in HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  3.76E+4nMAssay Description:Activation of wild-type human STING expressed in HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  1.76E+4nMAssay Description:Activation of wild-type human STING expressed in digitonin treated human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  2.71E+3nMAssay Description:Activation of wild-type human STING expressed in human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataEC50:  20nMAssay Description:Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB