BDBM50510977 CHEMBL4577527
SMILES [H][C@@]12C[C@@]1(SC(N)=N[C@]2(C)c1cc(NC(=O)c2cnc(OCC#C)cn2)cc(F)c1F)C(F)F
InChI Key InChIKey=NURKHPHCXJUBHN-DLPLYFIVSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50510977
Affinity DataIC50: 9.70nMAssay Description:Inhibition of BACE2 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BACE in HEK293 cells harboring APP Swedish mutant assessed as reduction in amyloid beta 40 level measured after overnight incubation by...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of recombinant CatD (unknown origin) expressed in CHO cells using FRET peptide substrate preincubated for 1 hr followed by substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+5nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of recombinant human BACE2 expressed in HEK293 cells co-transfected with N-terminal HA-tagged/C-terminal Myc tagged Mbeta chain of human P...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BACE1 (unknown origin) using FRET peptide substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRE...More data for this Ligand-Target Pair
Affinity DataIC50: 4.53E+5nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair