BDBM50511078 AS-1404::ASA-404::ASA404::CHEBI:75934::DMXAA::NSC-640488::Vadimezan

SMILES Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C

InChI Key InChIKey=XGOYIMQSIKSOBS-UHFFFAOYSA-N

Data  3 IC50  2 Kd  10 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50511078   

TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataKd:  130nMAssay Description:Binding affinity to mouse STING by ITC assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50:  1.50E+4nMAssay Description:Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50:  4.80E+4nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataKd:  710nMAssay Description:Binding affinity to mouse STING assessed as dissociation constantMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataIC50:  8.90E+4nMAssay Description:Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50511078(AS-1404 | ASA-404 | ASA404 | CHEBI:75934 | DMXAA |...)
Affinity DataEC50:  3.52E+4nMAssay Description:Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for...More data for this Ligand-Target Pair