BDBM50512574 CHEMBL4471410

SMILES Cn1c(cc2c(Cl)c(Cl)ccc12)C(=O)NC1(COC1)c1ccc(cc1)C(O)=O

InChI Key InChIKey=VTCQBZIYGBVVGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50512574   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512574(CHEMBL4471410)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human IDH1 expressed in Escherichia coli using isocitrate as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512574(CHEMBL4471410)
Affinity DataIC50:  153nMAssay Description:Inhibition of PHGDH (unknown origin) using 140 nM of PHGDH and 3-PG as substrate incubated for 20 mins in presence of NAD+, PSAT1, PSPH by diaphorase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512574(CHEMBL4471410)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MDH1 expressed in Escherichia coli using malate as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Meyer Cancer Center

Curated by ChEMBL
LigandPNGBDBM50512574(CHEMBL4471410)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human LDHA expressed in Escherichia coli using lactate as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed