BDBM50514037 CHEMBL4536439
SMILES CN1CCN(CC1)c1ccc2nc3C(=O)c4cc(F)ccc4-n3c(=O)c2c1
InChI Key InChIKey=OSSUXLNEXORTJB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50514037
Affinity DataKi: 170nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
Affinity DataKi: 6.92E+3nMAssay Description:Noncompetitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed inhibition constant using varying concentration...More data for this Ligand-Target Pair
Affinity DataKi: 1.99E+4nMAssay Description:Noncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 18 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynuren...More data for this Ligand-Target Pair
Affinity DataIC50: 4.68E+4nMAssay Description:Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of human IDO2 transfected in human U87MG cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated wi...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of IDO2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 h...More data for this Ligand-Target Pair