BDBM50514042 CHEMBL4578338

SMILES Fc1ccc-2c(c1)C(=O)c1nc3ccc(cc3c(=O)n-21)N1CCCCC1

InChI Key InChIKey=DCMJYRYVAMKYLN-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50514042   

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataKi:  1.56E+3nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataKi:  4.34E+3nMAssay Description:Uncompetitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed inhibition constant using varying concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataKi:  2.68E+4nMAssay Description:Uncompetitive inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 18 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  2.22E+4nMAssay Description:Inhibition of human IDO2 transfected in human U87MG cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  4.01E+4nMAssay Description:Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynuren...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed