BDBM50514202 CHEMBL4446369::US11274105, Example 179

SMILES [H][C@@]12CC[C@@]1([H])[C@@H](OCCN1CC(F)(F)C1)\C=C\CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)N(C)C)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1

InChI Key InChIKey=OCZBGAPIVMKKDK-HBUYLHAMSA-N

Data  2 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50514202   

LigandPNGBDBM50514202(CHEMBL4446369 | US11274105, Example 179)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
LigandPNGBDBM50514202(CHEMBL4446369 | US11274105, Example 179)
Affinity DataKi:  0.0620nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
LigandPNGBDBM50514202(CHEMBL4446369 | US11274105, Example 179)
Affinity DataIC50:  3.24nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
LigandPNGBDBM50514202(CHEMBL4446369 | US11274105, Example 179)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...More data for this Ligand-Target Pair
LigandPNGBDBM50514202(CHEMBL4446369 | US11274105, Example 179)
Affinity DataIC50:  0.300nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair