BDBM50514375 CHEMBL4515333
SMILES CCc1ccccc1-c1nnc(N2CCN(CC2)C(=O)C=C)c2cc(Cl)c(cc12)-c1c(O)cccc1F
InChI Key InChIKey=KWZPNWLSUXCBDL-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50514375
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Affinity DataIC50: 903nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair