BDBM50514375 CHEMBL4515333

SMILES CCc1ccccc1-c1nnc(N2CCN(CC2)C(=O)C=C)c2cc(Cl)c(cc12)-c1c(O)cccc1F

InChI Key InChIKey=KWZPNWLSUXCBDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514375   

TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514375(CHEMBL4515333)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514375(CHEMBL4515333)
Affinity DataIC50:  903nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed