BDBM50514382 CHEMBL4458945
SMILES C[C@H]1CN(CCN1c1nc(=O)n(-c2c(C)cccc2C)c2nc(c(Cl)cc12)-c1c(O)cccc1F)C(=O)C=C
InChI Key InChIKey=HHUULFVCGJTIAZ-SFHVURJKSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50514382
Affinity DataIC50: 199nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Affinity DataIC50: 306nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair