BDBM50515041 CHEMBL4125960

SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ccnc5[nH]ccc45)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=SMPGEBOIKULBCT-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50515041   

TargetTyrosine-protein kinase Fes/Fps(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  527nMAssay Description:Inhibition of FES (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  149nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  3.65E+3nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy Of Medical Science & Sichuan Provincial People'S Hospital

Curated by ChEMBL
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50:  536nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed