BDBM50519465 CHEMBL4466522

SMILES Cn1c2nc(Oc3cccc(OC(F)(F)F)c3)n(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O

InChI Key InChIKey=PRJHEJGMSOBHTO-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50519465   

TargetShort transient receptor potential channel 4(Homo sapiens)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  0.0120nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at -100 mV by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye b...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 4(Homo sapiens)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 4(Homo sapiens)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human TRPC4 expressed in HEK293 cells assessed as reduction in sphingosine-1-phosphate-induced current at +100 mV by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 1/4(Homo sapiens)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  0.0330nMAssay Description:Inhibition of human TRPC4/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 1/5(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50519465(CHEMBL4466522)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human TRPC5/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fl...More data for this Ligand-Target Pair