BDBM50522506 CHEMBL4562919
SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(CC(C)(C)O)cc(-c2c(Cl)cccc2Cl)c3=O)cc1
InChI Key InChIKey=USHVAFZIKXYYIM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50522506
TargetWee1-like protein kinase(Homo sapiens (Human))
Global Pharmaceutical Research And Development
Curated by ChEMBL
Global Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity to wild type N-terminal GST-tagged human WEE1 catalytic domain (215 to 646 residues) expressed in baculovirus expression system meas...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Global Pharmaceutical Research And Development
Curated by ChEMBL
Global Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataEC50: 4.02E+3nMAssay Description:Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphorylation at Tyr15 residue measured after 6 hrs by ELISAMore data for this Ligand-Target Pair