BDBM50522509 CHEMBL4444364

SMILES CN1Cc2cc(Nc3ncc4c(n3)c(C=C)cn(-c3c(Cl)cccc3Cl)c4=O)ccc2C2(CC2)C1

InChI Key InChIKey=YHGQCXIIDLUJNK-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50522509   

TargetWee1-like protein kinase(Homo sapiens (Human))
Global Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50522509(CHEMBL4444364)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to wild type N-terminal GST-tagged human WEE1 catalytic domain (215 to 646 residues) expressed in baculovirus expression system meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Global Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50522509(CHEMBL4444364)
Affinity DataEC50:  21nMAssay Description:Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphorylation at Tyr15 residue measured after 6 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed