BDBM50525709 CHEMBL4555143

SMILES CC(C)(C)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)n(n1)-c1ccccc1

InChI Key InChIKey=KZFPHKZQVCYHEZ-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50525709   

TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant full length human TrkB transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to recombinant human biotinylated and N-terminal DYKDDDDK-tagged TrkB kinase domain (456-822 residues) expressed in sf21 cells asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  11nMAssay Description:Inhibition of inactive recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  67nMAssay Description:Inhibition of activated recombinant human His-tagged TrkA expressed in baculovirus expression system preincubated for 20 mins followed by ATP/CSKtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor NF-E2 45 kDa subunit(Homo sapiens)
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  71nMAssay Description:Inhibition of activated recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant human His-tagged TrkA kinase domain (441-796 residues) expressed in baculovirus expression system incubated with enzyme/ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant full length human TrkA transfected in CHO cells assessed as inhibition of NGF-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50:  40nMAssay Description:Inhibition of inactive recombinant human His-tagged TrkB expressed in baculovirus expression system preincubated for 20 mins followed by ATP/SRCtide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataKd:  7.80nMAssay Description:Binding affinity to recombinant human biotinylated and N- terminal DYKDDDDK-tagged TrkA kinase domain (436-790 residues) expressed in Sf21 cells asse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Rattus norvegicus)
Zoetis

Curated by ChEMBL
LigandPNGBDBM50525709(CHEMBL4555143)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TrkA in rat PC12 cells assessed as reduction in beta-NGF-induced neurite outgrowth incubated for 7 days by live cell imaging analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed