BDBM50526811 Kzr-616

SMILES COc1ccc(cc1)[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CCCC1)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=GHYOCDFICYLMRF-UTIIJYGPSA-N

Data  30 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50526811   

TargetProteasome subunit beta type-8(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  0.688nMAssay Description:Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: >1.06E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  131nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  483nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  179nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  857nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  57nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  688nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  131nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  604nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  483nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  522nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  857nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: >1.06E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  688nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  604nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  623nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  179nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  430nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  0.623nMAssay Description:Inhibition of 20S proteasome beta 1i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  28nMAssay Description:Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  0.131nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  0.0390nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Mus musculus)
Kezar Life Sciences

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50:  57nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed