BDBM50527059 CHEMBL4452974

SMILES [H][C@]12CN(CCN1c1c(cnc3c(F)c(c(Cl)cc13)-c1c(O)cccc1F)N(C)C2=O)C(=O)C=C

InChI Key InChIKey=NZIBTXKFKUORFB-MRXNPFEDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50527059   

TargetGTPase KRas(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527059(CHEMBL4452974)
Affinity DataIC50:  18nMAssay Description:Inhibition of GDP bound biotinylated human C-terminal Avi/His6-tagged KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed