BDBM50527649 CHEMBL4467828
SMILES Clc1cc(cc2n(nnc12)-c1ccc2cn[nH]c2c1)-c1ccnn1Cc1ccc(cc1)C#N
InChI Key InChIKey=WHTYOOSKWPNGMT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50527649
TargetEctonucleoside triphosphate diphosphohydrolase 8(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human NTPDase 8 expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells in 2 % DMSO using AMP as substrate preincubated for 60 mins followed by substrate additio...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 1(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CD39 expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 50 min...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: <55nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 5 to 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 3(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human NTPDase 3 expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 5...More data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 2(Homo sapiens (Human))
Arcus Biosciences
Curated by ChEMBL
Arcus Biosciences
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human NTPDase 2 expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 5...More data for this Ligand-Target Pair