BDBM50529421 CHEMBL4530872

SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl

InChI Key InChIKey=MITRKIWBJVJRAM-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50529421   

TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Goldfinch Bio

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OAG-activated human TRPC6 channel expressed in HEK293 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Goldfinch Bio

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human ERG stably expressed in HEK293 cells measured at holding potential of -90 mV by manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Goldfinch Bio

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Nav1.5 stably expressed in CHO cells measured at holding potential of -80 mV by manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential protein 5(Rattus norvegicus)
Goldfinch Bio

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  180nMAssay Description:Inhibition of rosiglitazone-activated rat TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with holdi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  50nMAssay Description:Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked channel current measured at +80 mV by whole-cell volt...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  180nMAssay Description:Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 4(Homo sapiens)
Goldfinch Bio

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  290nMAssay Description:Inhibition of Englerin-activated human TRPC4 channel expressed in HEK293 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  211nMAssay Description:Inhibition of TRPC5 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50529421(CHEMBL4530872)
Affinity DataIC50:  280nMAssay Description:Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as decrease in current amplitude treated for 3 mins measured between +80 mV and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed