BDBM50530216 CHEMBL4582201

SMILES [H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1ccc(Cl)nc1

InChI Key InChIKey=NKHNTAYDCXZLFL-IZLWQMGWSA-N

Data  2 KI  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50530216   

TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7* nAChR in rat brain P2 membranes after 2.5 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  2.71E+3nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  430nMAssay Description:Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  2.71E+3nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human alpha7 nAChR expressed in mouse Neuro2a cells co-expressing chaperone NACHO assessed as increase in intracellular Ca2+ leve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50530216(CHEMBL4582201)
Affinity DataEC50:  430nMAssay Description:Agonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes after 4 to 5 days at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed