BDBM50530285 CHEMBL4568860

SMILES Clc1ccc(cc1Cl)-c1nsc(NC(=O)CC#N)n1

InChI Key InChIKey=QDAZJEMOLDXXHE-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50530285   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataIC50:  3.16E+3nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataEC50:  1.00E+4nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of Myr-GQQPGKVLGDQRRPSL(K-TAMRA)G-amide from N-terminal-truncated human c-ABL D382N mutant (46 to 534 residues) after 30 mins by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataEC50:  1.00E+4nMAssay Description:Induction of human c-ABL phosphorylation at Y245/Y412 residues in bacmam-induced HEK-MSR2 cell lysates by in-cell Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of Myr-GQQPGKVLGDQRRPSL(K-TAMRA)G-amide from N-terminal-truncated human c-ABL D382N mutant (46 to 534 residues) after 30 mins by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50530285(CHEMBL4568860)
Affinity DataIC50:  3.16E+3nMAssay Description:Activation of full length human 6His-tagged c-Abl expressed in baculovirus expression system using abltide as substrate after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed