BDBM50530315 CHEMBL4520531
SMILES OC(=O)c1ccc(Nc2nc(cs2)-c2ccc3ccccc3c2)cc1O
InChI Key InChIKey=HUECFCSRZKSRJF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50530315
TargetCasein kinase II subunit alpha'/beta(Homo sapiens (Human))
Universit£T Zu K£Ln
Curated by ChEMBL
Universit£T Zu K£Ln
Curated by ChEMBL
Affinity DataKi: 86nMAssay Description:ATP competitive inhibition of recombinant human CK2alpha2 (1 to 335 residues)/CK2beta2 (1 to 193 residues) expressed in Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha...More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 2.20E+3nMAssay Description:Binding affinity to CK2alpha (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 9.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
Affinity DataEC50: 9.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair