BDBM50530637 CHEMBL4591417
SMILES Cc1cc(Nc2nccc(n2)-c2sc(nc2-c2ccc(F)cc2)C2CCNCC2)ccn1
InChI Key InChIKey=ZDESNDWWUUVJLG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50530637
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human KCNQ1/KCNE1More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human aryl hydrocarbon receptorMore data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 4(Plasmodium falciparum (isolate 3D7))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK4 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr in presence of ATP-competitive kinase inhibitor by kino...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human L-type CaV1.2More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRR...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human KCNQ1/KCNE1More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 4(Plasmodium falciparum (isolate 3D7))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK4 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr in presence of ATP-competitive kinase inhibitor by kino...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by Q-patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human aryl hydrocarbon receptorMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRR...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human beta2 adrenoceptorMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding affinity to CK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human L-type CaV1.2More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 4(Plasmodium falciparum (isolate 3D7))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK4 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 4(Plasmodium falciparum (isolate 3D7))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK4 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr in presence of ATP-competitive kinase inhibitor by kino...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to CDPK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr in presence of ATP-competitive kinase inhibitor by kino...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding affinity to CK1 in Plasmodium falciparum 3D7 blood stage extract incubated for 1 hr by kinobeads based pull down assayMore data for this Ligand-Target Pair