BDBM50532757 CHEMBL4461070

SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1

InChI Key InChIKey=ODIUNTQOXRXOIV-UHFFFAOYSA-N

Data  12 IC50  2 Kd

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50532757   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataKd:  0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataKd:  0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50:  6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532757(CHEMBL4461070)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed