BDBM50532757 CHEMBL4461070
SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1
InChI Key InChIKey=ODIUNTQOXRXOIV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50532757
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataKd: 0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataKd: 0.900nMAssay Description:Binding affinity to MET (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 204nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany
Curated by ChEMBL
Sanofi-Aventis Germany
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline prod...More data for this Ligand-Target Pair