BDBM50532760 CHEMBL4457387

SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)C5CC5)sc4c3)n2n1

InChI Key InChIKey=TXOAIEIEDUCXGF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50532760   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  61nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  13nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  883nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  13nMAssay Description:Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  883nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  4nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  4nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532760(CHEMBL4457387)
Affinity DataIC50:  61nMAssay Description:Inhibition of phosphorylated MET L1195V mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed