BDBM50533232 CHEMBL4564126

SMILES Cc1cnc(cc1-n1c2ccncc2n(CC(N)=O)c1=O)-c1cc(Cl)ccc1F

InChI Key InChIKey=LVEUPFUJRKZPEN-UHFFFAOYSA-N

Data  8 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50533232   

TargetCytochrome P450 1A2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataEC50:  234nMAssay Description:Inhibition of ALK5 in TGF beta1-stimulated HEK293T cells by SMAD binding element-driven beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of MAP3K2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of MAP3K2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  25nMAssay Description:Inhibition of ALK5 (unknown origin) using fluorescein-labeled peptide substrate incubated for 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50:  25nMAssay Description:Inhibition of ALK5 (unknown origin) using fluorescein-labeled peptide substrate incubated for 90 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataIC50: <5.01E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50533232(CHEMBL4564126)
Affinity DataEC50:  234nMAssay Description:Inhibition of ALK5 in TGF beta1-stimulated HEK293T cells by SMAD binding element-driven beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed