BDBM50536032 CHEMBL4534001
SMILES COc1ccc(cc1)C(=O)N1CCc2c([nH]c3ccccc23)C1c1ccc(Cl)c(Cl)c1
InChI Key InChIKey=AKQFVWUCZTWDKB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50536032
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 285nMAssay Description:Inhibition of human ABCG2 expressed in baculovirus infected Sf9 cell membrane assessed as inhibition of vanadate sensitive quercetin-stimulated ATPas...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 233nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux pre-incubated for 30 mins before Hoechst 33342 addit...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 237nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in pheophorbide A efflux pre-incubated for 30 mins before Hoechst 33342 addi...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of sulfasalazine-stimulated ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substra...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of ABCG2 in topotecan-cultured human MCF7 cells using Hoechst 33342 as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 134nMAssay Description:Activation of ABCB1 ATPase activity (unknown origin) expressed in baculovirus infected Sf9 insect cells using ATP as substrate measured after 1 hr by...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human ABCG2 expressed in baculovirus infected Sf9 cell membrane assessed as inhibition of vanadate sensitive basal ATPase activity afte...More data for this Ligand-Target Pair