BDBM50539804 CHEMBL4640025::US11840533, Compound 71

SMILES CC(=O)Nc1cc(cc2n(ccc12)C(C)(c1ccccn1)c1ccccn1)-c1cn(C)c2c1cc[nH]c2=O

InChI Key InChIKey=RXFBVSDRBYMKRU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50539804   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Board of Trustees of The University of Illinois

US Patent
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Affinity DataKi: <10nMAssay Description:The BRD4 bromodomain 1 and/or 2 binding activity were measured by using the Cayman BRD4 bromodomain 1 or 2 TR-FRET Assay Kit (Item. No. 600520, 60053...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
The Board of Trustees of The University of Illinois

US Patent
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Affinity DataIC50:  8.30nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 1 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)
Affinity DataIC50:  22nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 2 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed