BDBM50546795 CHEMBL4777740

SMILES O=C(Cc1cccs1)N[C@@H](CS(=O)(=O)N1CCN(CC1)c1ccccn1)C(=O)NC1(CC1)C#N

InChI Key InChIKey=OGPQNXBUXVLCOW-SFHVURJKSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50546795   

TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546795(CHEMBL4777740)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546795(CHEMBL4777740)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of Cathepsin S in human Raji cells assessed as increase in Lip10 accumulation after 24 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed