BDBM50546993 CHEMBL4748782::US11247971, Cmpd ID 408::US11752138, Compound 249
SMILES Cc1ccc(s1)C#Cc1cc(ccc1F)-c1nn(c(CC2CC2)c1Cc1ccc(c(F)c1)S(N)(=O)=O)-c1nc(cs1)C(O)=O
InChI Key InChIKey=ADUJCIPBWYSFQX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50546993
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataKd: 0.0667nMAssay Description:Binding affinity to human His-tagged LDHA by SPR analysisMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 403nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 106nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 873nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair