BDBM50547890 CHEMBL4745699::US11377438, Example 46

SMILES NS(=O)(=O)c1cc(NC(=O)c2cc(CC3CC3)cnc2N2CCCC(F)(F)CC2)ccn1

InChI Key InChIKey=MLNHJUHDJAFYTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547890   

TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50547890(CHEMBL4745699 | US11377438, Example 46)
Affinity DataIC50:  1nMAssay Description:The following buffers were used for the QubeŽ recordings: External buffer for Nav1.8 QubeŽ recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50547890(CHEMBL4745699 | US11377438, Example 46)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed