BDBM50548670 CHEMBL4741924
SMILES CNC(=O)c1cn(C[C@H](F)CCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)cc(C)n3)nn2)nn1
InChI Key InChIKey=GEHZIZWHNLQFAS-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50548670
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to wild-type human partial length JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system by Kin...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetGlutaminase liver isoform, mitochondrial(Homo sapiens)
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human GLS2 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured for 20 mins by...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assayMore data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of GLS1 in human A549 cells assessed as reduction in conversion of glutamine to glutamate measured after 24 hrsMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
The University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrate measured after 45 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair