BDBM50552391 CHEMBL4777447

SMILES C[C@@H](Nc1c(Cl)c(C)nc2cc(F)c(nc12)-c1cnc(nc1)C(C)(C)O)c1cc(ccc1F)C#N

InChI Key InChIKey=UDLNDXDUOBMZIQ-GFCCVEGCSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50552391   

TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50:  25nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50:  27nMAssay Description:Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant His-tagged TNF-alpha-mediated E-selectin expression in HUVEC cells preincubated for 30 mins in presence of TNFalpha a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLymphotoxin-beta(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LTbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) in presence of BFC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCD40 ligand(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CD40L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor ligand superfamily member 6(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FasL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50552391(CHEMBL4777447)
Affinity DataIC50: >6.70E+3nMAssay Description:Inhibition of recombinant CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed