BDBM50553207 CHEMBL4786783

SMILES NC(=O)Cc1cccc(Nc2nc(C#C)c3nc[nH]c3n2)c1

InChI Key InChIKey=CJQGLUJHMXCLQY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50553207   

TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  62nMAssay Description:Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system assessed as inhibition of substrate phosphoryl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  830nMAssay Description:Inhibition of BMX (unknown origin) preincubated with enzyme for 15 mins followed by substrate/ATP challenge for 90 mins by ProfilerPro plate based la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  80nMAssay Description:Inhibition of Aurora A (unknown origin) preincubated with enzyme for 15 mins followed by substrate/ATP challenge for 90 mins by ProfilerPro plate bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  18nMAssay Description:Inhibition of human NEK2 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  550nMAssay Description:Inhibition of human MKK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  560nMAssay Description:Inhibition of human ChK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  320nMAssay Description:Inhibition of human MLK3 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  120nMAssay Description:Inhibition of human NAUK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  740nMAssay Description:Inhibition of human TBK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  240nMAssay Description:Inhibition of human TAK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  220nMAssay Description:Inhibition of human JAK2 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)
Affinity DataIC50:  270nMAssay Description:Inhibition of human MLK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed