BDBM50553528 CHEMBL4753780::US20230348415, Compound (S)-56
SMILES Cc1cc(nc(n1)N1CC[C@H](COc2ccccc2C(F)(F)F)C1)C(O)=O
InChI Key InChIKey=YNIAPSNMAZHUHD-LBPRGKRZSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50553528
TargetRetinol-binding protein(Human)
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 150nMAssay Description:Compound binding to RBP4 was assessed in the radiometric scintillation proximity (SPA) assay that was previously described (Cioffi, C. L. et al. 2014...More data for this Ligand-Target Pair
TargetRetinol-binding protein(Human)
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Compound binding to TTR was assessed in the fluorescence polarization assay. The assay measured competitive displacement of the fluorescent probe, FI...More data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]-all-trans-retinol from biotinylated human urine derived RBP4 measured after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Displacement of FITC-diclofenac from human plasma derived TTR measured after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Albany College Of Pharmacy And Health Sciences
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Displacement of [3H]-all-trans-retinol from MBP-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as reduction in untagged Eu-label...More data for this Ligand-Target Pair