BDBM50553528 CHEMBL4753780::US20230348415, Compound (S)-56

SMILES Cc1cc(nc(n1)N1CC[C@H](COc2ccccc2C(F)(F)F)C1)C(O)=O

InChI Key InChIKey=YNIAPSNMAZHUHD-LBPRGKRZSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50553528   

TargetRetinol-binding protein(Human)
The Trustees of Columbia University In The City of New York

US Patent
LigandPNGBDBM50553528(CHEMBL4753780 | US20230348415, Compound (S)-56)
Affinity DataIC50:  150nMAssay Description:Compound binding to RBP4 was assessed in the radiometric scintillation proximity (SPA) assay that was previously described (Cioffi, C. L. et al. 2014...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein(Human)
The Trustees of Columbia University In The City of New York

US Patent
LigandPNGBDBM50553528(CHEMBL4753780 | US20230348415, Compound (S)-56)
Affinity DataIC50:  3.90E+3nMAssay Description:Compound binding to TTR was assessed in the fluorescence polarization assay. The assay measured competitive displacement of the fluorescent probe, FI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50553528(CHEMBL4753780 | US20230348415, Compound (S)-56)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]-all-trans-retinol from biotinylated human urine derived RBP4 measured after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50553528(CHEMBL4753780 | US20230348415, Compound (S)-56)
Affinity DataIC50:  3.90E+3nMAssay Description:Displacement of FITC-diclofenac from human plasma derived TTR measured after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinol-binding protein 4(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50553528(CHEMBL4753780 | US20230348415, Compound (S)-56)
Affinity DataIC50:  750nMAssay Description:Displacement of [3H]-all-trans-retinol from MBP-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as reduction in untagged Eu-label...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed