BDBM50554386 CHEMBL4758484

SMILES C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1ccc(F)c2ccccc12

InChI Key InChIKey=LEKFHXQPKLJWJC-IDISGSTGSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50554386   

TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50554386(CHEMBL4758484)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50554386(CHEMBL4758484)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 chymotrypsin-like activity in human HeLa cells incubated for 2 hrs by proteasome-Glo assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50554386(CHEMBL4758484)
Affinity DataIC50:  39nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50554386(CHEMBL4758484)
Affinity DataIC50:  244nMAssay Description:Inhibition of human constitutive 20S proteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed