BDBM50555779 CHEMBL4800354

SMILES FC(F)(F)c1cccc(n1)-c1nc2NCCOCCCCc3cc(Cl)cc(Nc(n2)n1)c3

InChI Key InChIKey=SEWADTGOHXMXQV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50555779   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555779(CHEMBL4800354)
Affinity DataIC50:  12nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555779(CHEMBL4800354)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of wild type IDH2 (unknown origin) assessed as reduction in NADPH production using sodium(D)-isocitrate and NADP as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50555779(CHEMBL4800354)
Affinity DataIC50:  443nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed