BDBM50556074 CHEMBL4787695

SMILES Fc1ccc2C(=O)c3c(nnn3-c3ccc(F)c(Cl)c3)C(=O)c2c1

InChI Key InChIKey=KGLAAILBKHAJFQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50556074   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  5nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins by micropla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  4nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  98nMAssay Description:Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  59nMAssay Description:Inhibition of TDO in human A-172 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  5nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  98nMAssay Description:Inhibition of IDO1 in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  59nMAssay Description:Inhibition of TDO in human A 172 cells assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed