BDBM50557680 CHEMBL4741793

SMILES C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C(F)(F)F

InChI Key InChIKey=SFSLHKNGLMRBTO-ZETCQYMHSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50557680   

TargetPotassium channel subfamily T member 1(Homo sapiens)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily T member 1(Mus musculus)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  622nMAssay Description:Inhibition of recombinant wild type mouse KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily T member 1(Rattus norvegicus)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  545nMAssay Description:Inhibition of recombinant rat KNa1.1 expressed in human HEK-TREX cells at -80 mV holding potential by automated patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of human ERG by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily T member 1(Homo sapiens)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  40nMAssay Description:Inhibition of wild-type human Slack expressed in HEK293 cells measured by automated patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of Iks (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalcium-activated potassium channel subunit beta-1(Homo sapiens (Human))
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of BK (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily T member 2(Homo sapiens)
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of KCNT2 (unknown origin) by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Praxis Precision Medicines

Curated by ChEMBL
LigandPNGBDBM50557680(CHEMBL4741793)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human Nav1.5 by patch clamp analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed