BDBM50558812 CHEMBL4755698
SMILES Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc4OCOc4c3)c12
InChI Key InChIKey=RMTJSBZCZKCYHB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 57 hits for monomerid = 50558812
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 2.17E+4nMAssay Description:Inhibition of BTK (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pla Strategic Support Force Medical Center
Curated by ChEMBL
Pla Strategic Support Force Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pla Strategic Support Force Medical Center
Curated by ChEMBL
Pla Strategic Support Force Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated Q-patch clamp assayMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 5 mins followed by NADPH addition and further incubated for 10...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.19E+3nMAssay Description:Inhibition of human liver microsome CYP3A4 using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition and further incubated ...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.54E+3nMAssay Description:Inhibition of human liver microsome CYP2C9 using tolbutamide as substrate incubated for 5 mins followed by NADPH addition and further incubated for 1...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 4.17E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using omeprazole as substrate incubated for 5 mins followed by NADPH addition and further incubated for 1...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 6.01E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition and further incubated ...More data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.31E+9nMAssay Description:Inhibition of human liver microsome CYP2E1 using chlorzoxazone as substrate incubated for 5 mins followed by NADPH addition and further incubated for...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 3(Homo sapiens)
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of Tec (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 331nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 504nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human EGFR using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErBB2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ErBB4 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK7beta (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human JAK3 using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human JAK2 using Ulight-CAGAGAIETDKEYYTVKD as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CAMK1 (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CAMK2 (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CAMK4 (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CAMKK1 (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CAMKK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MEK1 using inactivated ERK2 as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human RSK2 using Histone H3 full length as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEKK2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MEKK3 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK4 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MKK6 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human p70S6K using CREBtide as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 657nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human FMS using Ulight-TK peptide as substrate incubate for 15 mins by LANCE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 146nMAssay Description:Inhibition of recombinant human YES using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 30 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of recombinant human FYN using biotinyl-beta Abeta-Abeta AYQAEENTYDEYEN as substrate incubate for 60 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 637nMAssay Description:Inhibition of recombinant human LCK using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 259nMAssay Description:Inhibition of recombinant human LYN using biotinyl-beta Abeta-Abeta AKVEKIGEGTYGVVYK as substrate incubate for 120 mins by LANCE assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human SRC using Ulight-Poly GAT[EAY(1:1:1)]n as substrate incubate for 10 mins by LANCE assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-6(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RSK4 (unknown origin)More data for this Ligand-Target Pair