BDBM50561221 CHEMBL4745473::US11377469, Example 95

SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COCP(O)(O)=O)n1ncc2c(NC3CCCC3)nc(Cl)nc12

InChI Key InChIKey=IVHVIBKVJIZKOC-RTWAVKEYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50561221   

Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  11nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: <500nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 2 5 mM Tris-HCL, pH 7.4, 0.01...More data for this Ligand-Target Pair
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of CD73 in human SK-OV-3 cells incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 1(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CD39 expressed in CHO cells incubated for 4 hrs before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human CD73 expressed in CHO cells incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetEctonucleoside triphosphate diphosphohydrolase 8(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NTPDase-8 expressed in CHO-K1 cells in presence of DNA/LTX mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Mus musculus)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  13nMAssay Description:Inhibition of mouse CD73 expressed in CHO cells incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
Target5'-nucleotidase(Mus musculus)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  3nMAssay Description:Inhibition of soluble mouse CD73 incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of A2AR (unknown origin) expressed in CHO cells assessed as reduction in NECA-stimulated cellular cAMP levels incubated for 90 mins by FRE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleoside triphosphate diphosphohydrolase 2(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NTPDase-2 expressed in CHO-K1 cells in presence of DNA/LTX mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleoside triphosphate diphosphohydrolase 3(Homo sapiens (Human))
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NTPDase-3 expressed in CHO-K1 cells in presence of DNA/LTX mixtureMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of soluble human CD73 incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair