BDBM50562506 CHEMBL4791168

SMILES COP(C)(=O)NCCCNc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O

InChI Key InChIKey=PNWWIOCNZXFHEC-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50562506   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  94nMAssay Description:Inhibition of N-terminal His-tagged human IDO1 expressed in Escherichia coli using L-Trp as substrate by UV absorbance methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  310nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human IDO2 (15 to 420 residues) expressed in Escherichia coli using L-Trp as substrate by UV absorba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  13nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-Trp as substrate incubated for 48 hrs by Ehrlich reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TDO (2 to 406 residues) expressed in Escherichia coli using L-Trp as substrate by UV absorbance...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  310nMAssay Description:Inhibition of IDO2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  94nMAssay Description:Inhibition of human N-terminal his-tagged IDO1 expressed in Escherichia coli using L-tryptophan as substrate by UV absorption based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  9.45E+4nMAssay Description:Inhibition of human recombinant N-terminal His tagged IDO1 expressed in Escherichia coli using L-Trp as substrate by measuring amount of N-formylkynu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human TDO by UV based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  94nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by absorbance based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed