BDBM50562606 CHEMBL4792256

SMILES CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(cc1)N1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=FIMUWTGRAKIIDX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50562606   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562606(CHEMBL4792256)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human FLAG-tagged EZH2 using H3K27me as substrate in presence of [3H]-SAM incubated for 30 mins by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562606(CHEMBL4792256)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed