BDBM50562615 CHEMBL4764756

SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(=O)n(Cc2cccc(Cl)c2)c1

InChI Key InChIKey=YQVUADHJKWJHAF-UHFFFAOYSA-N

Data  2 KI  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50562615   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataKi:  5.5nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataKi:  14nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) using BFC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin) using CEC as substrate measured after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2B6 (unknown origin) using EFC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using CEC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of recombinant MNK2 (unknown origin) in presence of ATP by ADP--Glo kinase assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  35nMAssay Description:Inhibition of Mnk2 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  18nMAssay Description:Inhibition of Mnk1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant MNK1 (unknown origin) in presence of ATP by ADP--Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) using AMMC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed