BDBM50562617 CHEMBL4752141

SMILES Nc1n[nH]c2cc(ccc12)-c1ccc(=O)n(Cc2ccccc2F)c1

InChI Key InChIKey=DUHHTOOYELYHTE-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50562617   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataKi:  11nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataKi:  14nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) using BFC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin) using CEC as substrate measured after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using CEC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin) using AMMC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 residues) expressed in baculovirus expression system using GRSRSRSRSR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant CYP2B6 (unknown origin) using EFC as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed