BDBM50567001 CHEMBL4873898

SMILES Cc1ccc(COC2CN(C2)C(=O)[C@H]2C[C@@]3(C2)COC(=O)N3)cc1Cl

InChI Key InChIKey=AKBHYCHPWZPGAH-QGGXVJLZSA-N

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50567001   

TargetMonoglyceride lipase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human His-tagged MAGL assessed as formation of arachidonic acid using 2-acylglycerol incubated for 10 mins by mass spectrometryMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataIC50:  13nMAssay Description:Inhibition of mouse MAGL assessed as formation of arachidonic acid using 2-acylglycerol incubated for 10 mins by mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human His-tagged MAGL assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ABHD6 expressed in Expi293 cells using p-nitrophenyl acetate as substrate incubated for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed