BDBM50567869 CHEMBL4878007

SMILES Nc1ncc(-c2cc3ccccc3o2)c(N2CCC3(CCNC3=O)CC2)c1Cl

InChI Key InChIKey=MTLHRGZTWNKSBV-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50567869   

TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataKi:  9nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) using RBER-CHKtide as substrate in presence of [32P]gammaATP incubated for 60 mins by microplate scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataKi:  51nMAssay Description:Inhibition of human LRRK2 using RLGRDKYKTLRQIRQ as substrate after 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataKi:  166nMAssay Description:Inhibition of human FMS using KKKSPGEYVNIEFG as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataKi:  242nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed