BDBM50567869 CHEMBL4878007
SMILES Nc1ncc(-c2cc3ccccc3o2)c(N2CCC3(CCNC3=O)CC2)c1Cl
InChI Key InChIKey=MTLHRGZTWNKSBV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50567869
Affinity DataKi: 9nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) using RBER-CHKtide as substrate in presence of [32P]gammaATP incubated for 60 mins by microplate scintil...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 51nMAssay Description:Inhibition of human LRRK2 using RLGRDKYKTLRQIRQ as substrate after 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry as...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 166nMAssay Description:Inhibition of human FMS using KKKSPGEYVNIEFG as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiomet...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 242nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometr...More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrateMore data for this Ligand-Target Pair