BDBM50569638 CHEMBL4874919

SMILES CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)c1ncc([nH]1)-c1cc2ccccc2nc1OC

InChI Key InChIKey=VNLUEMMOFCPORO-DEOSSOPVSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50569638   

TargetHistone deacetylase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataIC50:  770nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in 4'-hydroxy diclofenac level using diclofenac as substrate incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataEC50:  4.40E+3nMAssay Description:Activation of PXR (unknown origin) expressed in human DPX2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as induction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569638(CHEMBL4874919)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed