BDBM50569910 CHEMBL4848137

SMILES COc1cc2CCN(C=O)[C@@H](Cc3c[nH]c4c(Cl)cccc34)c2cc1OC

InChI Key InChIKey=FTUNSSCAXJNFIZ-SFHVURJKSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50569910   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant human PDE4D (83 to 416 residues) expressed in Escherichia coli BL21 (DE3) assessed as hydrolysis of [3H]-cAMP measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE1A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE2A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE3A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PDE11A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE6C assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PDE7A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PDE8A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PDE9A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569910(CHEMBL4848137)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human PDE5A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed